A WNT INHIBITORY FACTOR 1 (WIF-1) as tumor biomarker
Head of the research group: LÁSZLÓ PATTHY
Research concept
Numerous studies have shown that aberrant activation of the Wnt-pathway plays a significant role in carcinogenesis. The discovery that Wnt Inhibitory Factor 1 − a Wnt antagonist − is down-regulated in a variety of cancers made it clear that the expression level of WIF-1 is an important biomarker that may be exploited in diagnosis and precision therapy of tumours. We are developing, optimising and validating a quantitative method for monitoring the expression of the human WIF-1 gene in various types of normal and tumour tissues.