Investigation of complement biomarkers in inflammatory, autoimmune and oncological diseases

Head of the research group: MIHÁLY JÓZSI

Investigation of complement biomarkers in inflammatory, autoimmune and oncological diseases

Research concept

The complement system is an essential effector system of the humoral arm of innate immunity and plays an important role in maintaining immune homeostasis. The role of complement is recognized in an increasing number of pathological conditions, including infectious, inflammatory, autoimmune, neurological and oncological diseases. Our aim is to extract information on the state of the complement system under pathological and healthy conditions in order to identify characteristic changes or patterns. We are particularly interested in changes affecting the major complement regulator factor H and the factor H-related proteins. The results will potentially reveal novel disease-associated biomarkers, and contribute to our better understanding of the underlying pathomechanisms of certain inflammatory, autoimmune and oncological diseases.

Research services

For research purposes:

  • Detection and characterization of autoantibodies against complement proteins (factor H, factor B, C3b, C3 nephritic factor).
  • Measurement of complement protein levels (factor H, FHR5) in biological samples.
  • Detection of certain complement protein variants by Western blot (factor H, FHR proteins), functional characterization (e.g., as recombinant proteins).

Human resources 

  • Dr. Mihály Józsi, associate professor
  • Dr. Barbara Uzonyi, research scientist

Laboratories, rooms

Rooms of the Department of Immunology, ELTE TTK: Office room, laboratories, photography room, cold room

Equipments

Standard laboratory equipments: centrifuge, sterile box, incubators, etc.

Recent publications of the research group